I’m a music nerd and need to have iTunes running at all times, so I’ve taken full advantage of my options there with QS’ built-in iTunes abilities. It’s worth nothing that I use Option as my gateway into every 3rd party app - not as kosher as control, but hey - it’s right next to command!

Option+A: iTunes Artists search (A for artist!) Option+S: iTunes Song search (S for song!) Option+D: iTunes Search (D for “I’m next to A and S!”) Option+W: Current iTunes track (W for “What?”)

Add to that my use of Option+Q and Option+TAB for Which, and that’s a pretty full line-up we’ve got.

I also use F8 to launch NetNewsWire and Cmd+F8 to launch Gmail from scratch.