Have you seen the new Daylite?!
http://www.marketcircle.com/daylite
Dear God!
There is no way you couldn't do a bulletproof GTD in DayLite. The only reason I haven't been using it full time is because I can't figure out good and reliable ways to sync things back and forth to a mobile device out of it.
It is probably complete overkill for a lot of people, but if you want a nice CRM that manages workflow for you, its definatly worth a look. The newest version is hitting beta cycles now and its really quite impressive.
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