Have you seen the new Daylite?!
http://www.marketcircle.com/daylite
Dear God!
There is no way you couldn't do a bulletproof GTD in DayLite. The only reason I haven't been using it full time is because I can't figure out good and reliable ways to sync things back and forth to a mobile device out of it.
It is probably complete overkill for a lot of people, but if you want a nice CRM that manages workflow for you, its definatly worth a look. The newest version is hitting beta cycles now and its really quite impressive.
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I had to read your...
I had to read your "no way you couldn't do" bit about three times, as I thought you were at first shooting DOWN Daylite as a good GTD/etc application! (Then again, I'm operating on about 3 hours of sleep in the last 48 ;).)
But, back to Daylite, I've been testing it for a few days now and must say that I'm thoroughly impressed! If only things just felt a bit snappier, I'd be happier. (But, I shall survive..)